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KMID : 0964020120120010062
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Journal of the Korean Liver Cancer Study Group
2012 Volume.12 No. 1 p.62 ~ p.66
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A Case of Liver Transplantation after Combination of Sorafenib and Hepatic Arterial Infusion Chemotherapy in the Advanced Hepatocellular Carcinoma Patient with Portal Vein Thrombosis
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Song do-Seon
Song Myeong-Jun
Bae Si-Hyun
Choi Jong-Young
Yoon Seung-Kew
Chun Ho-Jong
Kim Dong-Goo
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Abstract
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Hepatocellular carcinoma (HCC) is the third most common malignancy in Korea where chronic hepatitis B virus is prevalent. More than 60-70% of HCC cases are diagnosed at an advanced stage that are not eligible for curative therapy such as surgical resection, liver transplantation, radiofrequency ablation, and percutaneous ethanol injection. According to Barcellona Clinic Liver Cancer (BCLC) staging and treatment, standard treatment of advanced HCC is sorafenib. And there are some reports that hepatic arterial infusion chemotherapy (HAIC) could be a beneficial therapeutic option for patients with advanced HCC. We report a case of advanced HCC with portal vein thrombosis that received liver transplantation after combination treatment of HAIC and sorafenib.
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KEYWORD
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Hepatocellular carcinoma, Sorafenib, Hepatic arterial infusion chemotherapy
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